Primary merkel cell carcinoma clinically presenting as deep oedematous mass of the groin, European Journal of Medical Research
Merkel cell carcinoma (MCC) is a relatively rare, polyomavirus associated, primary neuroendocrine carcinoma of the skin which is usually arising from dermal skin layers. However, the origin of MCC in the subcutaneous tissue is debatable. We report a 58-yearold female patient with an oedematous mass on her left groin that was firm in consistency and had no discoloration or other visible abnormality of the overlying skin. On histology and immunohistology the tumour was consistent with the diagnosis of MCC showing a predominant subcutanous growth pattern. Pelvic magnetic resonance tomography revealed a tumour conglomerate reaching from the subcutis of the left groin to the left paraaortal and parailiacal region indicating widespread lymphogenic metastisation. Despite complete medical work-up no other MCC primary could be detected. In conclusion, predominant subcutaneous growth pattern as well as tumour localization in the groin are uncommon features of MCC. MCC showing the aforementioned features may be associated with significant delay of diagnosis and therefore represents an unfavourable prognostic factor.
Merkel cell carcinoma: a report of 34 cases and literature review - ScienceDirect
Unknown primary Merkel cell carcinoma with cutaneous spread
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Patient with Merkel cell carcinoma of the right eyebrow (arrow).
Merkel cell carcinoma of the inguinal lymph node with an unknown primary site - KIM - 2009 - The Journal of Dermatology - Wiley Online Library
Diagnostics, Free Full-Text
Merkel cell carcinoma of lymph node with unknown primary has a significantly lower association with Merkel cell polyomavirus than its cutaneous counterpart
Abstracts from the 8th Drug Hypersensitivity Meeting (DHM) - 2018 - Clinical and Translational Allergy - Wiley Online Library
Diagnostics, Free Full-Text
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Australasian College of Dermatologists Abstracts Presented at the 49th Annual Scientific Meeting 14–17 May 2016 Perth, Western Australia - 2016 - Australasian Journal of Dermatology - Wiley Online Library
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